Tissue Specific Distribution and Dynamic Changes of 5-hydroxymethylcytosine in Mammalian Genome
نویسندگان
چکیده
1 TISSUE SPECIFIC DISTRIBUTION AND DYNAMIC CHANGES OF 5-HYDROXYMETHYLCYTOSINE IN MAMMALIAN GENOME Shannon Morey Kinney*, Hang Gyeong Chin*, Romualdas Vaisvila, Jurate Bitinaite, Yu Zheng, Pierre-Olivier Estève, Suhua Feng, Hume Stroud, Steven E. Jacobsen and Sriharsa Pradhan New England Biolabs, Inc; 240 County Road, Ipswich, Massachusets 01938. Howard Hughes Medical Institute; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095-1606 *Contributed equally to this study Running head: Tissue specific distribution of 5-hydroxymethylcytosine
منابع مشابه
Tissue-specific Distribution and Dynamic Changes of 5-Hydroxymethylcytosine in Mammalian Genomes*
Cytosine residues in the vertebrate genome are enzymatically modified to 5-methylcytosine, which participates in transcriptional repression of genes during development and disease progression. 5-Methylcytosine can be further enzymatically modified to 5-hydroxymethylcytosine by the TET family of methylcytosine dioxygenases. Analysis of 5-methylcytosine and 5-hydroxymethylcytosine is confounded, ...
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